The ISGC is a collaborative enterprise by researchers interested in the genetic basis of stroke. As such members pursue their own research as well as coming together under the ISGC banner to conduct larger, collaborative studies. Publications resulting from such studies, with the ISGC as an author, are listed here. Further details on the specific publications can be found by clicking on the links below. Links to individual researchers publications, in which the ISGC is not listed as an author, will not be listed here.
Our published recommendations:
DOI: 10.1161/STROKEAHA.114.006839
DOI: 10.1161/STROKEAHA.114.006851
Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: insights from multicenter data
Delucchi M, Bijlenga P, Morel S, Furrer R, Hostettler IC, Bakker MK, Bourcier R, Lindgren A, Maschke S, Bozinov O, Houlden H, Weeing D, Ruigrok YM, Wostrack M, Meyer B, Neidert MC, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study Investigators; Hirsch S, Spinner GR.
Comput Biol Med. 2026 Jan 15:201:111380. doi: 10.1016/j.compbiomed.2025.111380.
Elevated acute-phase plasma levels of S100A12 [EN-RAGE] are associated with vascular recurrence after ischemic strok
Björn Granelli, Annelie Angerfors, Sofia Furutjäll, Hanh Nguyen Larsson, Cecilia Brännmark, Björn Andersson, Tara M Stanne, Christina Jern.
European Stroke Journal, Volume 11, Issue 1, January 2026, https://doi.org/10.1093/esj/23969873251384439
Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis
Tchuisseu-Kwangoua LA, Omarov M, Shatunov A, Markus HS, Kamtchum-Tatuene J, Georgakis MK.
J Am Heart Assoc. 2025 Nov 4;14(21):e041814. doi: 10.1161/JAHA.124.041814.
Copy number variants and their association with intracerebral hemorrhage risk: a case-control study
Savvina Prapiadou, Carl D Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N Kimball, Chen Bowang, Hyacinth I Hyacinth, Jonathan Rosand, Christopher D Anderson, Caspar Grond-Ginsbach, Daniel Woo, Stacie L Demel.
Ann Clin Transl Neurol. 2025 Oct 29. doi: 10.1002/acn3.70230. Online ahead of print.
Blood Biospecimen Recommendations for Research on Stroke Outcomes and Recovery
Robynne G Braun, Matthew A Edwardson, Chad M Aldridge, Steven C Cramer, Carlos Cruchaga, Stefan T Engelter, Jin-Moo Lee, Jane M Maguire, Tara M Stanne, Boryana Stamova, Christopher Traenka, Cristina Gallego-Fabrega, Israel Fernandez Cadenas, Arne G Lindgren; International Stroke Genomics Consortium (ISGC) and the ISGC Global Alliance for Acute and Long-Term Outcome Studies
Stroke. 2025 Oct;56(10):e279-e290. doi: 10.1161/STROKEAHA.125.050793. Epub 2025 Sep 22. PMID: 40982604.
Rare variant association analysis uncovers involvement of VNN2 in stroke outcome
Estefanía Alcaide-Consuegra, Marina Mola-Caminal, Georgia Escaramís, Uxue Lazcano, Isabel Fernández-Pérez, Jaume Reig-Palou, Joan Jiménez-Balado, Eva Giralt-Steinhauer, Elisa Cuadrado-Godia, Angel Ois, Ana Rodríguez-Campello, Marta Vallverdú-Prats, Aina Medina-Dols, Carmen Jiménez, Silvia Tur, Rosa M Díaz-Navarro, Carlos David Bruque, Nuria Andreu-Somavilla, Irene González-Navarrete, Ferran Casals, Cristòfol Vives-Bauzà, Israel Fernández-Cadenas, Jordi Jiménez-Conde, Susanna Balcells, Raquel Rabionet.
Stroke. 2025 Sep;56(9):2571-2578. doi: 10.1161/STROKEAHA.124.049365. Epub 2025 Jun 11.
Development and internal validation of a clinical imaging-based stroke prediction model in a community cohort
J Am Heart Assoc. 2025 Sep 2;14(17):e041413. doi: 10.1161/JAHA.125.041413. Epub 2025 Aug 22.
Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease
Ray A, Alabarse P, Malik R, Sargurupremraj M, Bernhagen J, Dichgans M, Baumeister SE, Georgakis MK.
Am J Hum Genet. 2025 Jul 3;112(7):1597-1609.
Genetic Risk Scores in Stroke Research and Care
Bragazzi NL, Zhang L, Omarov M, Georgakis MK.
Stroke. 2025 Aug;56(8):2327-2336.
