The ISGC is a collaborative enterprise by researchers interested in the genetic basis of stroke. As such members pursue their own research as well as coming together under the ISGC banner to conduct larger, collaborative studies. Publications resulting from such studies, with the ISGC as an author, are listed here. Further details on the specific publications can be found by clicking on the links below. Links to individual researchers publications, in which the ISGC is not listed as an author, will not be listed here.
Our published recommendations:
DOI: 10.1161/STROKEAHA.114.006839
DOI: 10.1161/STROKEAHA.114.006851
Genomic insights into stroke recovery: cross-phenotype associations
Aldridge C, Braun R, Parodi L, Lohse K, Edwardson MA, Cole JW, Lindgren AG, Hsu FC, Keene K, Worrall B, Rosand J, Holman EA, Cramer SC.
Brain Communications. Volume 8, Issue 5, August 2026, https://doi.org/10.1093/braincomms/fcag322
Genetically determined levels of inflammation-related proteins and functional outcome after ischemic stroke: a Mendelian Randomization study
Angerfors A, Andersson B, Furutjäll S, Chong M, Jern C, Stanne TM.
Journal of Stroke. Volume 28, Issue 2, May 2026, https://doi:10.5853/jos.2025.05036
Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: insights from multicenter data
Delucchi M, Bijlenga P, Morel S, Furrer R, Hostettler IC, Bakker MK, Bourcier R, Lindgren A, Maschke S, Bozinov O, Houlden H, Weeing D, Ruigrok YM, Wostrack M, Meyer B, Neidert MC, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study Investigators; Hirsch S, Spinner GR.
Computers in Biology and Medicine. Volume 201, Article 111380, January 2026, https://doi: 10.1016/j.compbiomed.2025.111380
Elevated acute-phase plasma levels of S100A12 [EN-RAGE] are associated with vascular recurrence after ischemic stroke
Granelli G, Angerfors A, Furutjäll S, Nguyen Larsson H, Brännmark C, Andersson B, Stanne TM, Jern C.
European Stroke Journal, Volume 11, Issue 1, January 2026, https://doi.org/10.1093/esj/23969873251384439
Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis
Tchuisseu-Kwangoua LA, Omarov M, Shatunov A, Markus HS, Kamtchum-Tatuene J, Georgakis MK.
Journal of the American Heart Association. Volume 14, Issue 21, November 2025, https://doi.org/10.1161/JAHA.124.041814
Copy number variants and their association with intracerebral hemorrhage risk: a case-control study
Prapiadou S, Langefeld CD, Sekar P, Comeau M, Howard T, Kimball TN, Chen B, Hyacinth HI, Rosand J, Anderson CD, Grond-Ginsbach C, Woo D, Demel SL.
Annals of Clinical and Translational Neurology. Volume 13, Issue 3, October 2025, https://doi.org/10.1002/acn3.70230
Blood Biospecimen Recommendations for Research on Stroke Outcomes and Recovery
Robynne G Braun, Matthew A Edwardson, Chad M Aldridge, Steven C Cramer, Carlos Cruchaga, Stefan T Engelter, Jin-Moo Lee, Jane M Maguire, Tara M Stanne, Boryana Stamova, Christopher Traenka, Cristina Gallego-Fabrega, Israel Fernandez Cadenas, Arne G Lindgren; International Stroke Genomics Consortium (ISGC) and the ISGC Global Alliance for Acute and Long-Term Outcome Studies
Stroke. 2025 Oct;56(10):e279-e290. doi: 10.1161/STROKEAHA.125.050793. Epub 2025 Sep 22. PMID: 40982604.
Rare variant association analysis uncovers involvement of VNN2 in stroke outcome
Estefanía Alcaide-Consuegra, Marina Mola-Caminal, Georgia Escaramís, Uxue Lazcano, Isabel Fernández-Pérez, Jaume Reig-Palou, Joan Jiménez-Balado, Eva Giralt-Steinhauer, Elisa Cuadrado-Godia, Angel Ois, Ana Rodríguez-Campello, Marta Vallverdú-Prats, Aina Medina-Dols, Carmen Jiménez, Silvia Tur, Rosa M Díaz-Navarro, Carlos David Bruque, Nuria Andreu-Somavilla, Irene González-Navarrete, Ferran Casals, Cristòfol Vives-Bauzà, Israel Fernández-Cadenas, Jordi Jiménez-Conde, Susanna Balcells, Raquel Rabionet.
Stroke. 2025 Sep;56(9):2571-2578. doi: 10.1161/STROKEAHA.124.049365. Epub 2025 Jun 11.
Development and internal validation of a clinical imaging-based stroke prediction model in a community cohort
J Am Heart Assoc. 2025 Sep 2;14(17):e041413. doi: 10.1161/JAHA.125.041413. Epub 2025 Aug 22.
Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease
Ray A, Alabarse P, Malik R, Sargurupremraj M, Bernhagen J, Dichgans M, Baumeister SE, Georgakis MK.
Am J Hum Genet. 2025 Jul 3;112(7):1597-1609.