ISGC

The International Stroke Genetics Consortium (ISGC) was created in April 2007 by a group of 16 investigators from Europe and North America interested in stroke genetics research. Since then, the ISGC has held one international workshop every six months, hosted by ISGC members from around the world, and has become an international, multidisciplinary network of more than 200 stroke genetics investigators, representing over 20 countries in 5 continents.
 

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Would you like to donate to the ISGC Foundation to support future meetings, travel awards and ISGC administration? Learn more >

Workshops

The next ISGC Workshop will be held in Bordeaux, France hosted by Professor Stephanie Debette.

More information will be added here as it...

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Thank you for a great workshop in St. Louis!

...

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Thank you for a great workshop in Cambridge!

Working Groups

Among the goals of this committee are to increase efficiency of analyses and create an expert community to aid in solving problems faced by less experienced ISGC members.

Our mission is to decipher genetic determinants, both single gene and complex inheritance of early-onset stroke and cerebrovascular disease and search for the pathways through which they alter stroke susceptibility. We expect that this effort will lead to better treatments for Mendelian forms of stroke and will identify novel biological mechanisms that are also relevant to older-onset stroke.

This group undertakes harmonization of image characterization/measurement approaches across ISGC centers and contributes images to the ISGC-NINDS stroke imaging repository at MGH.

Formed in the fall of 2012, this group is responsible for harmonizing stroke outcome measures across member sites.

This working group is devoted to expanding ISGC participation to underrepresented regions and populations.

The goal of this group is uniting researchers whose goal is to use genetic and genomic tools to improve understanding of the pathophysiologic basis of cerebrovascular disease.

Projects

Members of the day

Professor Rustam Al-Shahi Salman

Professor Al-Shahi is interested in anything that bleeds in the brain, especially the clinical...

Dr Elizabeth G Holliday, PhD

Dr Holliday is a leading genetic analyst from Australia. She co-heads the ISGC analysis working...

Dr Foad Abd-Allah

Dr Abd-Allah graduated from Cairo University, Kasr El-Aini school of Medicine in 1994. He has...

Dr Jonathan Rosand, MD

Jonathan Rosand is Professor of Neurology at Harvard, appointed to the J.P. Kistler Endowed...

Dr Braxton D. Mitchell, MPH, PhD

Dr. Mitchell is Professor of Medicine and of Epidemiology & Public Health at the University...

New Papers

Genome-wide association meta-analysis of functional outcome after ischemic stroke.

Söderholm M, Pedersen A, Lorentzen E, Stanne TM, Bevan S, Olsson M, Cole JW, Fernandez-Cadenas I, Hankey GJ, Jimenez-Conde J, Jood K, Lee JM, Lemmens R, Levi C, Mitchell BD, Norrving B, Rannikmäe K, Rost NS, Rosand J, Rothwell PM, Scott R, Strbian D, Sturm JW, Sudlow C, Traylor M, Thijs V, Tatlisumak T, Woo D, Worrall BB, Maguire JM, Lindgren A, Jern C; International Stroke Genetics Consortium, the NINDS-SiGN Consortium, and the Genetics of Ischaemic Stroke Functional Outcome (GISCOME) Network.
Neurology. 2019 Mar 19;92(12):e1271-e1283. [ PUBMED ]

Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke.

Pfeiffer D, Chen B, Schlicht K, Ginsbach P, Abboud S, Bersano A, Bevan S, Brandt T, Caso V, Debette S, Erhart P, Freitag-Wolf S, Giacalone G, Grau AJ, Hayani E, Jern C, Jiménez-Conde J, Kloss M, Krawczak M, Lee JM, Lemmens R, Leys D, Lichy C, Maguire JM, Martin JJ, Metso AJ, Metso TM, Mitchell BD, Pezzini A, Rosand J, Rost NS, Stenman M, Tatlisumak T, Thijs V, Touzé E, Traenka C, Werner I, Woo D, Del Zotto E, Engelter ST, Kittner SJ, Cole JW, Grond-Ginsbach C, Lyrer PA, Lindgren; CADISP; GISCOME; SiGN studies; and ISGC.
Stroke. 2019 Feb;50(2):298-304. [ PUBMED ]

Genome-wide meta-analysis identifies 3 novel loci associated with stroke.

Malik R, Rannikmäe K, Traylor M, Georgakis MK, Sargurupremraj M, Markus HS, Hopewell JC, Debette S, Sudlow CLM, Dichgans M; MEGASTROKE consortium and the International Stroke Genetics Consortium.
Ann Neurol. 2018 Nov 1. doi: 10.1002/ana.25369. [ PUBMED ]

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.

Rutten-Jacobs LC, Larsson SC, Malik R, Rannikmäe K; MEGASTROKE consortium; International Stroke Genetics Consortium, Sudlow CL, Dichgans M, Markus HS, Traylor M.
BMJ. 2018 Oct 24;363:k4168. doi: 10.1136/bmj.k4168. [ PUBMED ]

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

Lubitz SA, Parsons OE, Anderson CD, Benjamin EJ, Malik R, Weng LC, Dichgans M, Sudlow CL, Rothwell PM, Rosand J, Ellinor PT, Markus HS, Traylor M; WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia.
Stroke. 2017 Jun;48(6):1451-1456 [ PUBMED ]